Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.

  title={Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease.},
  author={Jacques Belaiche and J. P. Desager and Yves Horsmans and Edouard V Louis},
  journal={Scandinavian journal of gastroenterology},
  volume={36 1},
BACKGROUND 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the intracellular metabolism of 6-MP into its active metabolites, 6-thioguanine nucleotides (6TGN) and 6methylmercaptopurine (6-MMP). Preliminary studies have suggested that the red blood cell concentration of 6TGN (RBC 6TGN) is a potential guide to therapy. The aims of the study were to evaluate the RBC… CONTINUE READING
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