Therapeutic drug monitoring of anti-infective agents in critically ill patients.

  title={Therapeutic drug monitoring of anti-infective agents in critically ill patients.},
  author={Nynke G. L. Jager and Reinier M. van Hest and Jeffrey Lipman and Fabio Silvio Taccone and Jason A. Roberts},
  journal={Expert review of clinical pharmacology},
  volume={9 7},
Initial adequate anti-infective therapy is associated with significantly improved clinical outcomes for patients with severe infections. However, in critically ill patients, several pathophysiological and/or iatrogenic factors may affect the pharmacokinetics of anti-infective agents leading to suboptimal drug exposure, in particular during the early phase of therapy. Therapeutic drug monitoring (TDM) may assist to overcome this problem. We discuss the available evidence on the use of TDM in… CONTINUE READING
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