Therapeutic dosimetry for Cf-252 neutron brachytherapy of pelvic cancer.

@article{Maruyama1985TherapeuticDF,
  title={Therapeutic dosimetry for Cf-252 neutron brachytherapy of pelvic cancer.},
  author={Yosh Maruyama and Joseph L. Beach and John D. Hazle and Mohammad Ashtari and Carter B. Schroy and M. H. Olson},
  journal={International journal of radiation oncology, biology, physics},
  year={1985},
  volume={11 5},
  pages={
          927-35
        }
}
252Cf (Cf) was used to treat tumors of the cervix and uterus with neutron brachytherapy (NT) in an ongoing clinical trial. Tandem and ovoids insertions were used and combinations of single and multiple applications along with high dose whole pelvic irradiation. Dosimetric analysis of treated cases for patterns of tissue dose were carried out. Tissue dose for Cf-NT was, in general, high for neutron components in the central pelvis only, and fell off rapidly with distance from the applicators… Expand
13 Citations
Clinical trial of 252Cf neutron brachytherapy vs. conventional radiotherapy for advanced cervical cancer.
252Cf, a neutron emitting radioactive transplutonium isotope, was tested for its efficacy against advanced bulky Stage III-IV cancers of the cervix in a clinical trial at the University of KentuckyExpand
252 Cf neutron brachytherapy and external 60 Co photon therapy in the curative management of primary or recurrent rectal cancer
TLDR
The results achieved by the use of 252 Cf neutron brachytherapy are encouraging to improve the treatment results in selected groups of patients with locally spread primary or recurrent rectal cancer. Expand
NEUTRON BRACHYTHERAPY IS BETTER THAN CONVENTIONAL RADIOTHERAPY IN ADVANCED CERVICAL CANCER
TLDR
Californium-252 (252Cf), a fast-neutron emitting radioisotope, was used for neutron brachytherapy of 82 patients with advanced cervical cancer, and in patients with stage IIIB disease, intracavitary therapy resulted in 54% 5-year survival compared with 12% in the caesium group. Expand
Boron neutron capture enhancement of 252Cf brachytherapy.
TLDR
It is concluded that there is a sufficiently high thermal neutron fluence present during californium brachytherapy for boron neutron capture dose augmentation to be feasible. Expand
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  • Y. Maruyama
  • Medicine
  • International journal of radiation oncology, biology, physics
  • 1988
TLDR
Localized neutron therapy using brachytherapy methods was found effective against radioresistance and bulky tumors, however, it needed to be used properly and with full appreciation of clinical oncology and the role of photon adjuvant therapy. Expand
Clinical study of relative biological effectiveness for cervical carcinoma treated by 252Cf neutrons and assessed by histological tumour eradication.
Clinical data of the University of Kentucky trial using californium (252Cf), or caesium (137Cs), are reviewed for dose-response based on the endpoint of tumour eradication estimated from hysterectomyExpand
Specimen histology after one or two preoperative CF-252 implants for bulky stage IB cervical cancer.
TLDR
The specimens obtained and studied after an initial Cf-252 insertion when the sources were newer and less decayed were more frequently negative for histological evidence of cancer than after the sources had decayed and 2 insertions were needed. Expand
Phase I‐II clinical trial of californium‐252. Treatment of stage IB carcinoma of the cervix
TLDR
Californium‐252 intracavitary therapy combined with whole‐pelvis photon radiotherapy resulted in 95% 2‐year and 91% 5‐year actuarial survival and there were 9% Grade II‐III complications by the Stockholm scale and 4% local failures. Expand
Feasibility study of californium‐252 for the therapy of stage IV cervical cancer
TLDR
Effective adjuvant therapy needs to be developed to use after the tumor debulking therapy, especially for Stage IVB disease, because of the frequency of disseminated metastases. Expand
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