Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.

@article{Iordanskiy2015TherapeuticDO,
  title={Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.},
  author={Sergey Iordanskiy and Rachel van Duyne and Gavin C. Sampey and Caitlin M Woodson and Kelsi Fry and M. D. Saifuddin and Jia Guo and Yuntao Wu and Fabio Romerio and Fatah Kashanchi},
  journal={Virology},
  year={2015},
  volume={485},
  pages={1-15}
}
The highly active antiretroviral therapy reduces HIV-1 RNA in plasma to undetectable levels. However, the virus continues to persist in the long-lived resting CD4(+) T cells, macrophages and astrocytes which form a viral reservoir in infected individuals. Reactivation of viral transcription is critical since the host immune response in combination with antiretroviral therapy may eradicate the virus. Using the chronically HIV-1 infected T lymphoblastoid and monocytic cell lines, primary… CONTINUE READING
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