Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects.

@article{Mitrophanov2012TherapeuticCO,
  title={Therapeutic correction of thrombin generation in dilution-induced coagulopathy: computational analysis based on a data set of healthy subjects.},
  author={Alexander Y. Mitrophanov and Frits R Rosendaal and Jaques Reifman},
  journal={The journal of trauma and acute care surgery},
  year={2012},
  volume={73 2 Suppl 1},
  pages={S95-S102}
}
BACKGROUND Prothrombin complex concentrates (PCCs), which contain different coagulation proteins, are attractive alternatives to the standard methods to treat dilution-induced (and, generally, traumatic) coagulopathy. We investigated the ability of a novel PCC composition to restore normal thrombin generation in diluted blood. The performance of the proposed PCC composition (coagulation factors [F] II, IX, and X and the anticoagulant antithrombin), designated PCC-AT, was compared with that of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Amodel for the stoichiometric regulation of blood coagulation

  • HockinMF, KJ Jones, SJ Everse, MannKG
  • J Biol Chem
  • 2002
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…