Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation.

@article{Nielson1986TherapeuticCO,
  title={Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation.},
  author={C. Nielson and J. Crowley and B. Cusack and R. Vestal},
  journal={The Journal of allergy and clinical immunology},
  year={1986},
  volume={78 4 Pt 1},
  pages={
          660-7
        }
}
  • C. Nielson, J. Crowley, +1 author R. Vestal
  • Published 1986
  • Medicine
  • The Journal of allergy and clinical immunology
  • Methylxanthines are primary agents used in treatment of hypersensitivity disease. Because polymorphonuclear leukocyte (PMN) activation is associated with generation of potent inflammatory mediators, xanthine effects on the PMN respiratory burst were studied. Enprofylline, a xanthine with important therapeutic potential, does not antagonize adenosine and was contrasted with theophylline. Although enprofylline was more potent at low concentrations, both drugs exhibited dose-dependent inhibition… CONTINUE READING
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