Therapeutic cancer vaccines in cervical cancer: phase I study of Lovaxin-C.

@article{Radulovi2009TherapeuticCV,
  title={Therapeutic cancer vaccines in cervical cancer: phase I study of Lovaxin-C.},
  author={Sini{\vs}a S Radulovi{\'c} and Mirjana V. Brankovic-Magic and Emina Malisic and Radmila Jankovic and Jelena D. Dobricic and Vesna Ple{\vs}inac-Karapand{\vz}i{\'c} and Paulo Cesar Maciag and John Rothman},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  year={2009},
  volume={14 Suppl 1},
  pages={S165-8}
}
Producing effective therapeutic vaccines has proved much more difficult and challenging than developing cancer preventive vaccines. Despite huge research in the area of cancer immunology, FDA/EMEA have not approved any type of cancer treatment vaccine so far. More than 99% of cervical cancers have detectable amounts of human papillomavirus (HPV) DNA. Integration of high-risk HPV into the host cell genome is followed by continual expression of HPV E6 and E7 oncoproteins, making them excellent… CONTINUE READING
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