Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.

@article{Garidou2012TherapeuticBO,
  title={Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.},
  author={Lucile Garidou and Sara Heydari and Selamawit Gossa and Dorian B. McGavern},
  journal={Journal of virology},
  year={2012},
  volume={86 13},
  pages={7060-71}
}
Persistent viral infections often overburden the immune system and are a major cause of disease in humans. During many persistent infections, antiviral T cells are maintained in a state of immune exhaustion characterized by diminished effector and helper functions. In mammalian systems, an extensive immune regulatory network exists to limit unwanted, potentially fatal immunopathology by inducing T cell exhaustion. However, this regulatory network at times overprotects the host and fosters viral… CONTINUE READING