Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia.

@article{Toyama2009TherapeuticBO,
  title={Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia.},
  author={Kentaro Toyama and Osamu Honmou and Kuniaki Harada and Junpei Suzuki and Kiyohiro Houkin and Hirofumi Hamada and Jeffery D Kocsis},
  journal={Experimental neurology},
  year={2009},
  volume={216 1},
  pages={47-55}
}
Intravenous transplantation of human mesenchymal stem cells (hMSCs) expanded from adult bone marrow ameliorates functional deficits in rat cerebral infarction models. Several hypotheses to account for the therapeutic mechanisms have been suggested, but angiogenesis is thought to be of critical importance. Recently, we have reported the therapeutic benefits of hMSCs which have been transfected with the angiopoietin-1 gene in a rat permanent middle cerebral artery occlusion (MCAO) model. To… CONTINUE READING