Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke.

@article{Shen2007TherapeuticBO,
  title={Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke.},
  author={L. H. Shen and Yi Li and Jieli Chen and Alex Zacharek and Qi Gao and Allissa Kapke and Mei Lu and Kim Raginski and Padmayathy Vanguri and Alan N Smith and Michael Chopp},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2007},
  volume={27 1},
  pages={6-13}
}
Bone marrow stromal cells (BMSCs) facilitate functional recovery in rats after stroke when administered acutely (1 day) or subacutely (7 days). In this study, we postponed the time of cell transplantation to 1 month after stroke. Female retired breeder rats were subjected to 2 h of middle cerebral artery occlusion (MCAo). Male BMSCs (3 x 10(6)) or phosphate-buffered saline were administered intravenously, and the animals were killed 3 months later. An additional population of nontreated rats… CONTINUE READING

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