Therapeutic approaches to diabetic nephropathy—beyond the RAS

  title={Therapeutic approaches to diabetic nephropathy—beyond the RAS},
  author={Beatriz Fern{\'a}ndez-Fern{\'a}ndez and Alberto Ortiz and Carmen G{\'o}mez-Guerrero and Jes{\'u}s Egido},
  journal={Nature Reviews Nephrology},
Despite improvements in glycaemic and blood pressure control, and the efficacy of renin–angiotensin system (RAS) blockade for proteinuria reduction, diabetic nephropathy is the most frequent cause of end-stage renal disease in developed countries. This finding is consistent with the hypothesis that key pathogenetic mechanisms leading to progression of renal disease are not modified or inactivated by current therapeutic approaches. Although extensive research has elucidated molecular signalling… CONTINUE READING
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