Therapeutic approaches in myelofibrosis.

  title={Therapeutic approaches in myelofibrosis.},
  author={Giovanni Barosi and Vittorio Rosti and Alessandro Maria Vannucchi},
  journal={Expert opinion on pharmacotherapy},
  volume={12 10},
INTRODUCTION Myeloproliferative neoplasm (MPN)-associated myelofibrosis is the most disabling of the classical Philadelphia-negative MPNs. The discovery that a gain-of-function mutation of JAK2 (JAK2V617F) is present in more than 60% of patients with MPN-associated myelofibrosis has provided a new target for innovative treatment strategies. AREAS COVERED This review discusses the indications and limitations of conventional therapies employed for the treatment of MPN-associated myelofibrosis… CONTINUE READING