Therapeutic applications of transcription factor decoy oligonucleotides.

  title={Therapeutic applications of transcription factor decoy oligonucleotides.},
  author={Michael J Mann and V J Dzau},
  journal={The Journal of clinical investigation},
  volume={106 9},
As alterations in gene expression have become a better understood component of normal development and disease pathogenesis, transcription factors and other regulators of gene expression have become an increasingly attractive target for potential therapeutic intervention. Transcription factors are generally nuclear proteins that play a critical role in gene regulation and can exert either a positive or negative effect on gene expression. These regulatory proteins bind specific sequences found in… CONTINUE READING


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