Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

  title={Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.},
  author={Nicola J Curtin and Csaba Szab{\'o}},
  journal={Molecular aspects of medicine},
  volume={34 6},
The aim of this article is to describe the current and potential clinical translation of pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) for the therapy of various diseases. The first section of the present review summarizes the available preclinical and clinical data with PARP inhibitors in various forms of cancer. In this context, the role of PARP in single-strand DNA break repair is relevant, leading to replication-associated lesions that cannot be repaired if homologous… CONTINUE READING
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