Therapeutic applications for ligands of retinoid receptors.

  title={Therapeutic applications for ligands of retinoid receptors.},
  author={Scott M. Thacher and Jayanand Vasudevan and Roshantha A. S. Chandraratna},
  journal={Current pharmaceutical design},
  volume={6 1},
Synthetic retinoids, ligands for the RAR and RXR members of the steroid/thyroid superfamily of nuclear hormone receptors, are used for the treatment of psoriasis, acne, photoaging and cancer. Retinoid mechanisms of action for these conditions largely involve effects on epithelial differentiation and modulation of inflammation with some impact on the immune system. Retinoid medicinal chemistry in recent years has identified ligands highly specific for one of the three RAR subtypes (RAR-alpha… CONTINUE READING
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