Therapeutic antitumor potential of endoglin-based DNA vaccine combined with immunomodulatory agents

Abstract

Therapy targeting tumor blood vessels ought to inhibit tumor growth. However, tumors become refractory to antiangiogenic drugs. Therefore, therapeutic solutions should be sought to address cellular resistance to antiangiogenic therapy. In this regard, reversal of the proangiogenic and immunosuppressive phenotype of cancer cells, and the shift of the tumor… (More)
DOI: 10.1038/gt.2012.28

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