Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts

@article{Agnusdei2014TherapeuticAT,
  title={Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts},
  author={Valentina Agnusdei and Sonia Anna Minuzzo and Chiara Frasson and Angela Grassi and Fumiko T Axelrod and Sanjeev Satyal and Austin Gurney and Timothy C Hoey and Elena Seganfreddo and Giuseppe Basso and S. Valtorta and Rosa Maria Moresco and Alberto Amadori and Stefano Indraccolo},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={278-288}
}
T-acute lymphoblastic leukemia (T-ALL) is characterized by several genetic alterations and poor prognosis in about 20–25% of patients. Notably, about 60% of T-ALL shows increased Notch1 activity, due to activating NOTCH1 mutations or alterations in the FBW7 gene, which confer to the cell a strong growth advantage. Therapeutic targeting of Notch signaling could be clinically relevant, especially for chemotherapy refractory patients. This study investigated the therapeutic efficacy of a novel… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
37 Citations
42 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

patients with high risk of transformation and poor outcome

  • R Kridel, B Meissner, S Rogic, M Boyle, A Telenius, B Woolcock
  • Leukemia
  • 2013

Similar Papers

Loading similar papers…