Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts

  title={Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts},
  author={Valentina Agnusdei and Sonia Anna Minuzzo and Chiara Frasson and Angela Grassi and Fumiko T Axelrod and Sanjeev Satyal and Austin Gurney and Timothy C Hoey and Elena Seganfreddo and Giuseppe Basso and S. Valtorta and Rosa Maria Moresco and Alberto Amadori and Stefano Indraccolo},
T-acute lymphoblastic leukemia (T-ALL) is characterized by several genetic alterations and poor prognosis in about 20–25% of patients. Notably, about 60% of T-ALL shows increased Notch1 activity, due to activating NOTCH1 mutations or alterations in the FBW7 gene, which confer to the cell a strong growth advantage. Therapeutic targeting of Notch signaling could be clinically relevant, especially for chemotherapy refractory patients. This study investigated the therapeutic efficacy of a novel… CONTINUE READING
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patients with high risk of transformation and poor outcome

  • R Kridel, B Meissner, S Rogic, M Boyle, A Telenius, B Woolcock
  • Leukemia
  • 2013

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