Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo.


We have previously shown that angiomotin (Amot) mediates angiostatin inhibition of endothelial migration and tube formation in vitro. A crucial role of angiomotin in regulating endothelial cell motility is indicated by the findings that knockdown of Amot in zebrafish reduces the number of filopodia of endothelial tip cells and severely impairs the migration… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.