Therapeutic antibodies for brain disorders.

@article{Paul2011TherapeuticAF,
  title={Therapeutic antibodies for brain disorders.},
  author={Steven M Paul},
  journal={Science translational medicine},
  year={2011},
  volume={3 84},
  pages={
          84ps20
        }
}
The enzyme β-secretase (BACE1) remains an important potential disease-modifying target for developing drugs to treat Alzheimer's disease. However, finding selective BACE1 inhibitors that can penetrate the brain has proved challenging. In this issue of Science Translational Medicine, a pair of studies describes a new approach to inhibiting BACE1 using a human monoclonal antibody that uses receptor-mediated transcytosis to cross the blood brain barrier (Atwal et al. and Yu et al.). The authors… CONTINUE READING
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