Therapeutic angiogenesis of human early endothelial progenitor cells is enhanced by thrombomodulin.

@article{Li2011TherapeuticAO,
  title={Therapeutic angiogenesis of human early endothelial progenitor cells is enhanced by thrombomodulin.},
  author={Jiun-Yi Li and Cheng-Huang Su and Yih-Jer Wu and T Tien and C Hsieh and Chih-Hao Chen and Ya-Ming Tseng and G Shi and H. -C. Wu and Cheng-Ho Tsai and F N Lin and H. -S. Yeh},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 11},
  pages={2518-25}
}
OBJECTIVE We examined the effect of thrombomodulin (TM) domains 2 and 3 (TMD23) on human early endothelial progenitor cells (EPCs). METHODS AND RESULTS TM was expressed and released by human EPCs cultured from peripheral blood mononuclear cells (PBMCs). Addition of TMD23 (100 ng/mL) to the cultured PBMCs increased the colony-forming units, chemotactic motility, matrix metalloproteinase activity, and interleukin-8 secretion but decreased tumor necrosis factor-α (TNF-α) release. Analysis of the… CONTINUE READING
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