Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product.

@article{Lasala2012TherapeuticAI,
  title={Therapeutic angiogenesis in patients with severe limb ischemia by transplantation of a combination stem cell product.},
  author={Gabriel P Lasala and Jos{\'e} Aniceto Silva and Jos{\'e} J. Minguell},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2012},
  volume={144 2},
  pages={377-82}
}
OBJECTIVE Angiogenesis involves the interplay of endothelial progenitor cells, pericytes, growth factors, and cellular matrix components. The use of mesenchymal stem cells, which are closely related to pericytes and produce diverse angiogenic growth factors and matrix molecules, seems to be a promising therapeutic modality. We postulate that the use of a combination cell product (mesenchymal stem cells in conjunction with a source of endothelial progenitor cells) is safe and efficient and may… CONTINUE READING
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