Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects.

@article{Zachary2011TherapeuticAF,
  title={Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects.},
  author={Ian C. Zachary and Robert D Morgan},
  journal={Heart},
  year={2011},
  volume={97 3},
  pages={181-9}
}
Since the discovery of vascular endothelial growth factor (VEGF), therapeutic angiogenesis has attracted interest as an alternative treatment for ischaemic heart and peripheral disease. In parallel, the view has also gained ground that angiogenesis has an important role in the pathogenesis of atherosclerotic disease and its clinical sequelae. These conflicting perspectives have both been based on a large quantity of preclinical data obtained from mainly small rodent models of disease. However… CONTINUE READING

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