Therapeutic angiogenesis: a case for targeted, regulated gene delivery.

  title={Therapeutic angiogenesis: a case for targeted, regulated gene delivery.},
  author={Keith A. Webster},
  journal={Critical reviews in eukaryotic gene expression},
  volume={10 2},
  • Keith A. Webster
  • Published 2000 in Critical reviews in eukaryotic gene expression
Blood and vascular disorders underlie a plethora of pathological conditions and are the single most frequent cause of human disease. Eliminated or restricted blood flow to tissues as a result of vessel dysfunction results in the disruption of oxygen and nutrient delivery and the accumulation of waste metabolites. Cells cannot survive extended severe ischemia but may be able to adapt to a moderate condition where diffusion to and from bordering nonischemic regions sustain vital functions. Under… CONTINUE READING

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