Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

  title={Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.},
  author={Alvaro Lassaletta and Michal Zapotocky and Matthew Mistry and Vijay Ramaswamy and Marion Honnorat and Rahul Krishnatry and Ana S Guerreiro Stucklin and Nataliya Zhukova and Anthony Arnoldo and Scott Ryall and Catriona Ling and Tara McKeown and Jim Loukides and Ofelia Cruz and Carmen de Torres and Cheng-Ying Ho and Roger J. Packer and Ruth Tatevossian and Ibrahim Qaddoumi and J H Harreld and James D Dalton and Jean M. Mulcahy-Levy and Nicholas Foreman and Matthias A Karajannis and Shiyang Wang and Matija Snuderl and Amulya Nageswara Rao and Caterina Giannini and Mark W Kieran and Keith L Ligon and Maria Luisa Garr{\'e} and Paolo Nozza and Samantha Mascelli and Alessandro Raso and Sabine M{\"u}ller and Theodore P. Nicolaides and Karen C Holanda Silva and Romain Perbet and Alexandre Vasiljevic and C{\'e}cile Faure Conter and Didier Frappaz and Sarah E S Leary and C. Crane and Aden Ka-Yin Chan and Ho-keung Ng and Zhenpeng Shi and Ying Mao and Elizabeth Finch and David D Eisenstat and Bev Wilson and Anne Sophie Carret and P{\'e}ter Hauser and David Sumerauer and Lenka Krskov{\'a} and Valerie Larouche and Adam Fleming and Shayna M. Zelcer and Nada Jabado and James T. Rutka and Peter Dirks and Michael D. Taylor and Shiyi Chen and Ute Katharina Bartels and Annie Huang and D W Ellison and Eric Bouffet and Cynthia E. Hawkins and U Tabori},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={35 25},
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared with a large international independent cohort of… CONTINUE READING
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