Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats.

@article{Fletcher1998TherapeuticAO,
  title={Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats.},
  author={Daniel S. Fletcher and William R. Widmer and S. Luell and Annette Christen and Chadwick J Orevillo and Shambhu Shah and Denise Visco},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={284 2},
  pages={714-21}
}
Up-regulation of the inducible isoform of nitric oxide synthase (iNOS) was determined during the development of adjuvant-induced arthritis in the rat. iNOS enzymatic activity, measured in spleen tissue, appeared and increased coincidentally with the appearance and degree of paw swelling and joint destruction in this arthritis model, when measured on days 0 through 21 subsequent to inoculation of the rats with adjuvant. The increase in enzymatic activity was paralleled by an increase in the… CONTINUE READING

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The effects of a selective cyclooxygenase-2 (COX-2) inhibitor on adjuvant-induced arthritis in the rat

  • D Visco, R Widmer, +9 authors E MacIntyre
  • Presented at the 10th International Conference on…
  • 1996
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