Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia

  title={Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia},
  author={Séverine Loisel and Karine Le Ster and Mich{\`e}le Meyer and Christian Berthou and Pierre Y. Youinou and Jean Pierre Kolb and Christian Billard},
  journal={Journal of Hematology \& Oncology},
  pages={49 - 49}
BackgroundWe previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphocytic leukemia (CLL) and leukemia B cell lines.ResultsHere, we investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals… 
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