Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.

@article{Obana2010TherapeuticAO,
  title={Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.},
  author={Masanori Obana and Makiko Maeda and Koji Takeda and Akiko Hayama and Tomomi Mohri and Tomomi Yamashita and Yoshikazu Nakaoka and Issei Komuro and Kiyoshi Takeda and Goro Matsumiya and Junichi Azuma and Yasushi Fujio},
  journal={Circulation},
  year={2010},
  volume={121 5},
  pages={684-91}
}
BACKGROUND Glycoprotein 130 is the common receptor subunit for the interleukin (IL)-6 cytokine family. Previously, we reported that pretreatment of IL-11, an IL-6 family cytokine, activates the glycoprotein 130 signaling pathway in cardiomyocytes and prevents ischemia/reperfusion injury in vivo; however, its long-term effects on cardiac remodeling after myocardial infarction (MI) remain to be elucidated. METHODS AND RESULTS MI was generated by ligating the left coronary artery in C57BL/6 mice… CONTINUE READING