Therapeutic Trials in Acute Gouty Arthritis

  title={Therapeutic Trials in Acute Gouty Arthritis},
  author={M. H. Levin and S. Marcus and D. Strange and R. Swezey},
  journal={Annals of the Rheumatic Diseases},
  pages={233 - 236}
Colchicine remains the agent of choice in the treatment of acute gouty arthritis. In recent years valuable additions to the therapeutic armamentarium in this disease include ACTH, cortisone, hydrocortisone acetate, prednisone, and Butazolidin (Wolfson, Hunt, Cohn, Robinson, and Duff, 1950; Gutman and Yu, 1950, 1952; Freyberg, 1955; Hartung, 1955; Steinbrocker, Neustadt, and Ehrlich, 1954). All of these are effective systemically, and in addition hydrocortisone acetate appears beneficial when… Expand
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Treatment of acute gouty arthritis with demecolcine.
Skin rash, depilation, and bone marrow depression, manifested by leukopenia, thromb openia, and anemia, have occurred in patients with chronic myelogenous leukemia and other neoplastic diseases, and the chemical similarity of demecolcine and colchicine was decided to observe its effect in patients. Expand
Hematologic toxicity after the use of desacetylmethylcolchicine in the treatment of gouty arthritis.
Recent reports have indicated that because of the rarity of gastrointestinal toxicity, Colcemide might be a more useful agent than colchicine and indeed might even replace it in the management of acute gouty arthritis. Expand
Effect of desacetylmethylcolchicine (Colcemide) in acute gouty arthritis
Although gastrointestinal symptoms were avoided, other more serious undesirable effects such as bone-marrow depression and alopecia are cited. Expand
Demecolcine toxicity: a case report of severe hematopoietic toxicity and a review of the literature.
A patient with acute gouty arthritis, in whom multiple toxic effects resulted from demecolcine treatment, is described, with specific reference to the hematopoietic system. Expand
Acute gouty arthritis provoked by cerebrovascular disease.
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Intra-Articular Hydrocortisone (Compound F) Acetate *
Clinical and synovial fluid changes observed after intra-articular injections of hydrocortisone acetate in patients with rheumatoid arthritis are dealt with. Expand
The effect of intravenous demecolcine (colcemid) on acute gout.
Extensive laboratory study by Schar, Loustalot, and Gross demonstrated that, in all animal species, demecolcine is considerably less toxic than colchicine. Expand
Effects of adrenocorticotropic hormone (ACTH) in gout.
The available evidence does not appear to justify the view that the pituitary and/or adrenal glands play a central role in the pathogenesis of gout, and the use of ACTH is neither feasible nor desirable at present. Expand
Allergic factors in gout.
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The complete reversibility of the arthritic attacks in the early stages and their irreversibility in the later phases, terminating in crippling chronic gouty arthritis with tophaceous deposits, is generally recognized. Expand
Intra-articular hydrocortisone in the treatment of arthritis.
An attempt is made to suppress arthritic inflammation by injecting petrolatum, iodized oil, lactic acid, procaine or antibiotics directly into the affected synovial tissue. Expand
Desacetylmethylcolchicine in Treatment of Myeloid Leukaemia
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however (for it was the literal soul of the life of the Redeemer, John xv. io), is the peculiar token of fellowship with the Redeemer. That love to God (what is meant here is not God’s love to men)Expand
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