Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors

@inproceedings{Miller2011TherapeuticST,
  title={Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors},
  author={Claudia P. Miller and Melissa M. Singh and Nilsa Rivera-Del Valle and Christa A. Manton and Joya Chandra},
  booktitle={Journal of biomedicine & biotechnology},
  year={2011}
}
Histone acetylation is a posttranslational modification that plays a role in regulating gene expression. More recently, other nonhistone proteins have been identified to be acetylated which can regulate their function, stability, localization, or interaction with other molecules. Modulating acetylation with histone deacetylase inhibitors (HDACi) has been validated to have anticancer effects in preclinical and clinical cancer models. This has led to development and approval of the first HDACi… CONTINUE READING
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