Therapeutic Strategies for Laryngeal Manifestations of Gastroesophageal Reflux Disease

  title={Therapeutic Strategies for Laryngeal Manifestations of Gastroesophageal Reflux Disease},
  author={Elif Saritas Yuksel and Michael Fredrick Vaezi},
  journal={Journal of Clinical Gastroenterology},
  • E. YukselM. Vaezi
  • Published 1 March 2013
  • Medicine
  • Journal of Clinical Gastroenterology
Gastroesophageal reflux disease is increasingly associated with ear, nose, and throat symptoms, including laryngitis. Many patients are unaware of the gastroesophageal etiology of their symptoms. A variety of criteria are used to diagnose this condition, including laryngoscopy, esophagogastroduodenoscopy, and the use of ambulatory pH and impedance monitoring. However, no test serves as the gold standard for the diagnosis given their lack of sensitivity and specificity for reflux disease… 

Supraesophageal Reflux Disease (SERD)

Supraesophareal reflux disease is a form of acid reflux manifested not by heartburn but rather by respiratory or laryngeal symptoms, and the nonspecific nature of the symptoms and the difficulty in diagnosis it is accepted that failure of a properly administered therapeutic trial should prompt further investigation for another diagnosis.

Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease: a definitive diagnostic test?

Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease.

Laryngopharyngeal reflux: to be or not to be?

  • D. Castell
  • Medicine
    Journal of clinical gastroenterology
  • 2013
This issue of the journal, Doctors Yuksel and Vaezi have provided a comprehensive and thoughtful review of the therapeutic approaches available to the patient with possible LPR, and they provide a discussion of the evidence or lack thereof, for effective therapies for this potential condition.

Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms

Clinical and psychological differences between GERD patients with or without LPR symptoms are investigated.

Aspiration-related pulmonary syndromes.

The broadening spectrum of aspiration-related pulmonary syndromes is discussed with a focus on presenting features and diagnostic aspects.

Laryngopharyngeal pH Monitoring in Patients With Idiopathic Pulmonary Fibrosis

Patients with IPF may have basic and acidic LPR, which may likely occur at upright and supine position, respectively, and Ryan index may not accurately reflect LPR in patients with IPf.

Laryngopharyngeal pH monitoring in patients with interstitial lung diseases

Patients with ILDs may have LPR and basic and acidic LPR may likely occur at upright and supine position, respectively, according to Ryan index, which may not accurately reflect LPR.

Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms

The quality of life in patients with laryngopharyngeal reflux symptoms is also significantly impaired, however, the impact of LPR symptoms on HRQL in GERD patients has not been studied.


The aim of this study was to estimate the burden of gastroesophageal UH?X(�GLVHDVHLQ�,UDQ� � the most common gastrointestinal tract disorders which is a threat to the quality of life.



Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association.

  • M. VaeziD. HicksT. AbelsonJ. Richter
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2003
The reasons for this controversy are discussed and the recent data attempting to clarify the cause and effect relationship between GERD and ENT are highlighted.

Otolaryngologic manifestations of gastroesophageal reflux.

  • E. Gaynor
  • Medicine
    The American journal of gastroenterology
  • 1991
The symptoms and pathophysiology of gastroesophageal reflux, especially when the classic symptoms of reflux are absent, is frequently overlooked as a cause of these problems.

Role of refluxed acid in pathogenesis of laryngeal disorders.

Laryngopharyngeal reflux: More questions than answers

The current understanding of the pathophysiology is reviewed and current diagnostic tests and treatment regimens in patients with suspected laryngopharyngeal reflux are discussed.

Diagnosis and management of laryngopharyngeal reflux disease

  • H. Mahieu
  • Medicine
    Current opinion in otolaryngology & head and neck surgery
  • 2006
Laryngopharyngeal reflux disease is a diagnosis by exclusion, and resolution of symptoms following a 4-month trial of high-dose proton pump inhibitor twice daily is considered proof of the initial diagnosis.

Laryngeal Manifestations of Gastroesophageal Reflux Before and After Treatment With Omeprazole

In patients with symptomatic reflux laryngitis, standardized videolaryngostroboscopic evaluation and, if the patient is hoarse, acoustic analysis are useful techniques to aid diagnosis and monitor therapy.

Review article: gastro‐oesophageal reflux and laryngeal symptoms

  • A. Fraser
  • Medicine
    Alimentary pharmacology & therapeutics
  • 1994
Given the lack of specificity for routine diagnostic tests for gastro‐oesophageal reflux, it is necessary to perform ambulatory pH monitoring for a secure diagnosis in patients with laryngeal symptoms and no clear information on efflcacy can be provided until placebo‐controlled randomised studies are available.

Empirical Trials in Treatment of Gastroesophageal Reflux Disease

  • R. Fass
  • Medicine
    Digestive Diseases
  • 2000
The PPI empirical trial should be considered as the initial diagnostic step in patients with the disease spectrum of GERD, due to a marked decrease in utilization of invasive diagnostic tests.