Therapeutic Strategies for Alzheimer’s Disease

  title={Therapeutic Strategies for Alzheimer’s Disease},
  author={Donna M. Barten and Charles F. Albright},
  journal={Molecular Neurobiology},
Therapeutic approaches for Alzheimer’s disease (AD) are guided by four disease characteristics: amyloid plaques, neurofibrillar tangles (NFT), neurodegeneration, and dementia. Amyloid plaques are composed largely of 4 kDa β-amyloid (Aβ) peptides, with the more amyloidogenic, 42 amino acid form (Aβ42) as the primary species. Because multiple, rare mutations that cause early-onset, familial AD lead to increased production or aggregation of Aβ42, amyloid therapeutics aim to reduce the amount of… CONTINUE READING
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