Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus

  title={Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus},
  author={Liqing Zang and Yasuhito Shimada and Hiroko Nakayama and Wenbiao Chen and Ayaka Okamoto and Hiroyuki Koide and Naoto Oku and Takehisa Dewa and Masayuki Shiota and Norihiro Nishimura},
  journal={Frontiers in Genetics},
Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia and is influenced by genetic and environmental factors. Optimum T2DM management involves early diagnosis and effective glucose-lowering therapies. Further research is warranted to improve our understanding of T2DM pathophysiology and reveal potential roles of genetic predisposition. We have previously developed an obesity-induced diabetic zebrafish model that shares common pathological pathways with humans and may be… 

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