Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.

  title={Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.},
  author={Gautam Sethi and Bokyung Sung and Bharat Bhushan Aggarwal},
  journal={Advances in experimental medicine and biology},
Vascular endothelial growth inhibitor (VEGI, TNFSF-15) is a novel member of the tumor necrosis factor (TNF) superfamily that consists of 174 amino acids and exhibits a 20% to 30% sequence homology to other members of the TNF superfamily. The VEGI gene is expressed as a transmembrane protein predominantly in endothelial cells and induced generally in response to inflammatory stimuli. It mediates most of its cellular responses through the interaction of the death receptor-3. VEGI activates… CONTINUE READING


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