Therapeutic Options for Acute Cough Due to Upper Respiratory Infections in Children

  title={Therapeutic Options for Acute Cough Due to Upper Respiratory Infections in Children},
  author={Ian M. Paul},
  • I. Paul
  • Published 1 February 2012
  • Medicine
  • Lung
Cough due to upper respiratory tract infections (URIs) is one of the most frequent complaints encountered by pediatric health-care providers, and one of the most disruptive symptoms for children and families. Despite the frequency of URIs, there is limited evidence to support the few therapeutic agents currently available in the United States (US) to treat acute cough due to URI. Published, well-designed, contemporary research supporting the efficacy of narcotics (codeine, hydrocodone) and US… 

Efficacy of levodropropizine in pediatric cough.

Cough in children.

ough in Children

There is no scientific evidence to justify the use of over-the-counter cough remedies (anti-tussives, mucolytics and/or antihistamines), as they could have potentially serious side effects, and thus should not be prescribed in children.

[Diagnostic and treatment approach of chronic cough in childhood].

The symptomatic approach with antitussives and mucolytic drugs is exceptionally necessary and should be considered for some situations of nonspecific cough without any specific disease association.

Natural remedies for acute post-viral cough in children.

There is an urgent need to perform rigorous studies that confirm the natural products' efficacy and safety for relieving post-viral acute cough.

Antitussive Drugs—Past, Present, and Future

There has been a considerable increase in understanding of the cough reflex over the last decade that has led to a number of promising new targets for antitussive drugs being identified and thus giving some hope of new drugs being available in the not too distant future for the treatment of this often debilitating symptom.

Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study

Both polysaccharide-resin-honey and carbocysteine cough syrups were well tolerated in children over 2 years of age and both nocturnal and daytime cough improved, as did sleep quality for both children and parents.

Utilização de Xaropes para a Tosse em Idade Pediátrica

Symptomatic therapy in children includes central or peripheral antitussives, demulcents and mucolytics, which can be considered to ameliorate comfort in children older than two years-old, for short periods, and integrated in an investigation and medical revaluation plan.

Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents

The results suggest that honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents.



Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings.

There is no good evidence for or against the effectiveness of OTC medicines in acute cough, and higher quality evidence is needed to determine the effective of self care treatments for acute cough.

Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials

OTC cough medicines do not appear more effective than placebo in relieving symptoms of acute cough, and based on the available evidence from a small number of studies, it cannot be recommended as a first line treatment for children with acute cough.

Recommendations for the assessment and management of cough in children

Current evidence has highlighted that parental reporting of the frequency and severity of a child’s cough is unreliable compared with objective measures, and this is especially true for nocturnal cough.

Use of codeine- and dextromethorphan-containing cough remedies in children. American Academy of Pediatrics. Committee on Drugs.

Education of patients and parents about the lack of proven antitussive effects of cough and cold preparations and the potential risks of these products is needed.

Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms

In a comparison of VR, petrolatum, and no treatment, parents rated VR most favorably for symptomatic relief of their child's nocturnal cough, congestion, and sleep difficulty caused by upper respiratory tract infection.

A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents.

It is demonstrated that receiving a 2.5-mL dose of honey before sleep has a more alleviating effect on URIs-induced cough compared with DM and DPH doses.

Guidelines for evaluating chronic cough in pediatrics: ACCP evidence-based clinical practice guidelines.

Recommendations are derived from a systematic review of the literature and were integrated with expert opinion, and are not intended to be used as a protocol for the management of all children with a coughing illness.

Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents.

In a comparison of honey, DM, and no treatment, parents rated honey most favorably for symptomatic relief of their child's nocturnal cough and sleep difficulty due to upper respiratory tract infection.

Tape recorder for evaluation of coughs in children.

Experimental production of cough by chemical or mechanical irritants is subject to certain limitations and criticisms, and the healthy volunteer after repeated exposure develops a tolerance to the irritant, especially when the latter is citric acid.

Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trial.