Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis.

  title={Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis.},
  author={Peter M Elias},
  journal={Annals of dermatology},
  volume={22 3},
In this review, I first provide relevant background information about normal epidermal barrier structure and function. I then update recent information about how inherited defects in either filaggrin and/or in the serine protease inhibitor, lymphoepithelial Kazal-type inhibitor 1, converge to stimulate the development of atopic dermatitis (AD). Next I explain the multiple mechanisms whereby a primary barrier abnormality in AD can lead to inflammation. Furthermore, I explore how certain acquired… CONTINUE READING

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