Therapeutic Efficacy of a Doxorubicin Immunoconjugate in a Preclinical Model of Spontaneous Metastatic Human Melanoma 1

@inproceedings{Sham2006TherapeuticEO,
  title={Therapeutic Efficacy of a Doxorubicin Immunoconjugate in a Preclinical Model of Spontaneous Metastatic Human Melanoma 1},
  author={Gowsala P. Sham and Paul J Martin and Ralph A. Reisfeld and Barbara M. Mueller},
  year={2006}
}
Doxorubicin (DOX) was conjugated to a monoclonal antibody lui Ah 425) directed against the human epidermal growth factor receptor. The immunoreactivity of these conjugates, with an average of six to eight molecules of DOX per antibody, was largely conserved, and their in vitro cytotoxicity against metastatic human melanoma cells (M24 met) was improved over… CONTINUE READING