Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats

@inproceedings{Warzecha2017TherapeuticEO,
  title={Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats},
  author={Zygmunt Warzecha and Paweł Sendur and Piotr Ceranowicz and Jakub Cieszkowski and Marcin Dembiński and Ryszard Sendur and Joanna Bonior and Jolanta Jaworek and Tadeusz Ambroży and Rafał Olszanecki and Beata Kuśnierz-Cabala and Kaczmarzyk Tomasz and Romana A Tomaszewska and Artur Dembiński},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Intravascular activation of coagulation is observed in acute pancreatitis and is related to the severity of this inflammation. The aim of our study was to evaluate the impact of acenocoumarol therapy on the course of acute pancreatitis induced in male rats by pancreatic ischemia followed by reperfusion. Acenocoumarol at a dose of 50, 100, or 150 µg/kg/dose was administered intragastrically once a day, starting the first dose 24 h after the initiation of pancreatic reperfusion. RESULTS… CONTINUE READING
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