Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry.

@article{Haouala2009TherapeuticDM,
  title={Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry.},
  author={Amina Haouala and Boris Zanolari and Bertrand Rochat and Milagros Montemurro and Khalil Zaman and Michel Andr{\'e} Duchosal and H. B. Ris and Serge Leyvraz and Nicolas Widmer and Laurent A Decosterd},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 22},
  pages={1982-96}
}
The treatment of some cancer patients has shifted from traditional, non-specific cytotoxic chemotherapy to chronic treatment with molecular targeted therapies. Imatinib mesylate, a selective inhibitor of tyrosine kinases (TKIs) is the most prominent example of this new era and has opened the way to the development of several additional TKIs, including sunitinib, nilotinib, dasatinib, sorafenib and lapatinib, in the treatment of various hematological malignancies and solid tumors. All these… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

References

Publications referenced by this paper.
Showing 1-7 of 7 references

F

R. A. Larson, B. J. Druker
Guilhot, S.G. O’Brien, G.J. Riviere, T. Krahnke, I. Gathmann, Y. Wang, Blood 111 • 2008
View 7 Excerpts
Highly Influenced

M

S. Picard, K. Titier, +8 authors N. Moore
Molimard, F.X. Mahon, Blood 109 • 2007
View 10 Excerpts
Highly Influenced

Br

N. Widmer, L. A. Decosterd, +6 authors T. Buclin
J. Cancer 98 • 2008
View 2 Excerpts

Lancet Oncol

J. F. Apperley
8 • 2007
View 1 Excerpt

Clin

B. Peng, P. Lloyd, H. Schran
Pharmacokinet. 44 • 2005
View 1 Excerpt

J

D. S. Krause, R. A. Van Etten, N. Engl
Med. 353 • 2005

Nat

R. Capdeville, E. Buchdunger, J. Zimmermann, A. Matter
Rev. Drug Discov. 1 • 2002

Similar Papers

Loading similar papers…