Therapeutic Drug Monitoring of Antiepileptic Drugs by Use of Saliva

@article{Patsalos2013TherapeuticDM,
  title={Therapeutic Drug Monitoring of Antiepileptic Drugs by Use of Saliva},
  author={Philip N Patsalos and David J. Berry},
  journal={Therapeutic Drug Monitoring},
  year={2013},
  volume={35},
  pages={4–29}
}
Abstract:Blood (serum/plasma) antiepileptic drug (AED) therapeutic drug monitoring (TDM) has proven to be an invaluable surrogate marker for individualizing and optimizing the drug management of patients with epilepsy. Since 1989, there has been an exponential increase in AEDs with 23 currently licensed for clinical use, and recently, there has been renewed and extensive interest in the use of saliva as an alternative matrix for AED TDM. The advantages of saliva include the fact that for many… 
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The mechanism of action, pharmacokinetics, drug–drug interactions, and safety/tolerability profiles of the main AEDs currently used in children and adolescents are reviewed, paying particular regard to issues of relevance when treating this patient population.
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