Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain

  title={Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain},
  author={N. Volkow and G. Wang and J. Fowler and J. Logan and M. Gerasimov and L. Maynard and Y. Ding and S. Gatley and A. Gifford and D. Franceschi},
  journal={The Journal of Neuroscience},
  pages={RC121 - RC121}
  • N. Volkow, G. Wang, +7 authors D. Franceschi
  • Published 2001
  • Psychology, Medicine
  • The Journal of Neuroscience
  • Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD), yet the mechanisms responsible for its therapeutic effects are poorly understood. Whereas methylphenidate blocks the dopamine transporter (main mechanism for removal of extracellular dopamine), it is unclear whether at doses used therapeutically it significantly changes extracellular dopamine (DA) concentration. Here we used positron… CONTINUE READING
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