Therapeutic Discovery Trans , trans , trans-[ PtIV ( N 3 ) 2 ( OH ) 2 ( py ) ( NH 3 ) ] : A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism

@inproceedings{Westendorf2012TherapeuticDT,
  title={Therapeutic Discovery Trans , trans , trans-[ PtIV ( N 3 ) 2 ( OH ) 2 ( py ) ( NH 3 ) ] : A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism},
  author={Aron F. Westendorf and Julie A. Woods and Katharina Korpis and Nicola J. Farrer and Luca Salassa and Kim M Robinson and Virginia C. L. Appleyard and Karen Murray and Alastair M. Thompson and Peter J Sadler and Patrick J. Bednarski},
  year={2012}
}
Photoactivatable Pt diazido complexes have unusual photobiologic properties. We show here that trans, trans,trans-[Pt(N3)2(OH)2(py)(NH3)] complex 3 is a potent photoactivated cytotoxin toward human cancer cells in culture, with an average IC50 value in 13 cell lines of 55 28 mmol/L after 30 minutes (0.12 mW/cm) photoactivation with UVA, although visible… CONTINUE READING