Therapeutic Discovery Silencing IL-13 R a 2 Promotes Glioblastoma Cell Death via Endogenous Signaling

Glioblastomamultiforme (GBM) is one of the most lethal forms of cancer, with a survival rate of only 13% to 27%within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique IL-13Ra2 decoy receptor prevents GBM apoptosis. This receptor has a high affinity for interleukin13 (IL-13), binds the cytokine, and… CONTINUE READING