Therapeutic Cardiac‐Targeted Delivery of miR‐1 Reverses Pressure Overload–Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling

Abstract

BACKGROUND MicroRNAs (miRNAs) play a key role in the development of heart failure, and recent studies have shown that the muscle-specific miR-1 is a key regulator of cardiac hypertrophy. We tested the hypothesis that chronic restoration of miR-1 gene expression in vivo will regress hypertrophy and protect against adverse cardiac remodeling induced by… (More)
DOI: 10.1161/JAHA.113.000078

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Cite this paper

@inproceedings{Karakikes2013TherapeuticCD, title={Therapeutic Cardiac‐Targeted Delivery of miR‐1 Reverses Pressure Overload–Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling}, author={Ioannis Karakikes and Antoine H Chaanine and Soojeong Kang and Bertrand N. Mukete and Dongtak Jeong and Shihong Zhang and Roger J. Hajjar and Djamel Lebeche}, booktitle={Journal of the American Heart Association}, year={2013} }