Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer.

@article{Liu2016TheranosticNF,
  title={Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer.},
  author={Yanlan Liu and Viswanath Gunda and Xi Zhu and Xiaoding Xu and Jun Wu and Diana Askhatova and Omid C Farokhzad and Sareh Parangi and Jinjun Shi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 28},
  pages={7750-5}
}
Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi nanotechnology represents a promising strategy for cancer therapy through nanoparticle (NP) -mediated delivery of RNAi agents (e.g., siRNA) to solid tumors for specific silencing of target genes driving growth and… CONTINUE READING

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Systemic siRNA delivery using these NPs efficiently silences the expression of V - Raf murine sarcoma viral oncogene homolog B ( BRAF ) in tumor tissues and significantly suppresses tumor growth and metastasis in an orthotopic mouse model of ATC .
Systemic siRNA delivery using these NPs efficiently silences the expression of V - Raf murine sarcoma viral oncogene homolog B ( BRAF ) in tumor tissues and significantly suppresses tumor growth and metastasis in an orthotopic mouse model of ATC .
Anaplastic thyroid cancer ( ATC ) , one of the most aggressive solid tumors , is characterized by rapid tumor growth and severe metastasis to other organs .
Anaplastic thyroid cancer ( ATC ) , one of the most aggressive solid tumors , is characterized by rapid tumor growth and severe metastasis to other organs .
Systemic siRNA delivery using these NPs efficiently silences the expression of V - Raf murine sarcoma viral oncogene homolog B ( BRAF ) in tumor tissues and significantly suppresses tumor growth and metastasis in an orthotopic mouse model of ATC .
Systemic siRNA delivery using these NPs efficiently silences the expression of V - Raf murine sarcoma viral oncogene homolog B ( BRAF ) in tumor tissues and significantly suppresses tumor growth and metastasis in an orthotopic mouse model of ATC .
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