Theranostic nanoparticles enhance the response of glioblastomas to radiation

@article{Wu2019TheranosticNE,
  title={Theranostic nanoparticles enhance the response of glioblastomas to radiation},
  author={W. Wu and Jessica L Klockow and S. Mohanty and Kimberly S. Ku and M. Aghighi and S. Melemenidis and Zixin Chen and K. Li and G. Morais and Ning Zhao and J. Schlegel and E. Graves and J. Rao and P. Loadman and R. Falconer and S. Mukherjee and F. Chin and H. Daldrup-Link},
  journal={Nanotheranostics},
  year={2019},
  volume={3},
  pages={299 - 310}
}
Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major concern. We recently developed a cross-linked iron oxide nanoparticle conjugated to azademethylcolchicine (CLIO-ICT) to target and eradicate a subpopulation of quiescent cells, glioblastoma initiating cells (GICs), which could be a reason for radioresistance… Expand
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