Theranostic Studies of Human Sodium Iodide Symporter Imaging and Therapy Using 188Re: A Human Glioma Study in Mice

@inproceedings{Guo2014TheranosticSO,
  title={Theranostic Studies of Human Sodium Iodide Symporter Imaging and Therapy Using 188Re: A Human Glioma Study in Mice},
  author={Rui Guo and Min Zhang and Yun Xi and Yufei Ma and Sheng Liang and Shuo Shi and Ying Ying Miao and Biao Li},
  booktitle={PloS one},
  year={2014}
}
OBJECTIVE To investigate the role of 188Re in human sodium iodide symporter (hNIS) theranostic gene-mediated human glioma imaging and therapy in model mice. METHODS The human glioma cell line U87 was transfected with recombinant lentivirus encoding the hNIS gene under the control of cytomegalovirus promoter (U87-hNIS). The uptake and efflux of 188Re were determined after incubating the cells with 188Re. 188Re uptake experiments in the presence of various concentrations of sodium perchlorate… CONTINUE READING