Thep53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers

Abstract

We previously reported that introduction of the wild-typep53 gene into human cancer cells with deletedp53 enhanced apoptosis induced by chemotherapy [Fujiwara et al. (1994) Cancer Res 54∶2287]. This suggests thatp53 status could be a potent determinant of the therapeutic efficacy of DNA-damaging cancer therapy. We analyzed 24 patients with gastric or… (More)
DOI: 10.1007/BF01220804

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