Theory of a-Helix-to-Random-Coil Transition of Two-Chain, Coiled Coils. Application of the Augmented Theory to Thermal Denaturation of a-Tropomyosin

Abstract

The statistical mechanical theory of the helix-to-random-coil transition in two-chain, a-helical coiled coils has recently been augmented by inclusion of the effects of loop entropy and out-of-register (“mismatched”) structures. This theory is applied to experimental data on non-cross-linked a-tropomyosin at nearly neutral and at acidic pH, using extant… (More)

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