Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.

@article{Dasbiswas2018TheoryOE,
  title={Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.},
  author={K. Dasbiswas and E. Hannezo and N. Gov},
  journal={Biophysical journal},
  year={2018},
  volume={114 4},
  pages={
          968-977
        }
}
  • K. Dasbiswas, E. Hannezo, N. Gov
  • Published 2018
  • Medicine, Physics, Biology, Chemistry
  • Biophysical journal
  • Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration… CONTINUE READING

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