Theory and statistics of detecting synergism between two active drugs: cocaine and buprenorphine

@article{Tallarida1997TheoryAS,
  title={Theory and statistics of detecting synergism between two active drugs: cocaine and buprenorphine},
  author={Ronald J. Tallarida and Heather L. Kimmel and Stephen G. Holtzman},
  journal={Psychopharmacology},
  year={1997},
  volume={133},
  pages={378-382}
}
 This article discusses the theory and statistical aspects in the design and analysis of experiments to detect synergism between two drugs that produce overtly similar effects. The current analysis extends and simplifies previously published work in this area. Application is made to a study by Kimmel et al. in this issue that examined the combined action of buprenorphine and cocaine in producing turning in rats having unilateral nigrostriatal lesions produced by 6-hydroxydopamine. The use of… CONTINUE READING

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